130 years of cyclodextrin discovery for health, food, agriculture, and the industry: a review

Cyclodextrins are a group of cyclic oligosaccharides obtained by enzymatic degradation starch. They remarkable macrocyclic molecules that have led major theoretical and practical advances in chemistry, biology, biochemistry, health science, agriculture. Their molecular structure is composed hydrophobic cavity can encapsulate other compounds to form inclusion complexes through host–guest interactions. This unique feature at the origin many applications. their derivatives wide variety applications almost all sectors industry, including pharmacy, medicine, foods, cosmetics, chromatography, catalysis, biotechnology, textile industry. Villiers published first reference cyclodextrins 1891, since then, these continued fascinate academia Currently, more than 2000 publications on each year. On occasion 130th anniversary discovery, this review, we present an historical overview development cyclodextrins. First, discovery chemical studies Then, main results during 1911–1970 exploration period discussed. A third part presents landmarks from 1970 day.